当测试图像提出看不见的分布时，深层分割模型通常会面临故障风险。改善模型鲁棒性针对这些风险的鲁棒性对于深层模型的大规模临床应用至关重要。在这项研究中，受到人类学习周期的启发，我们提出了一个新颖的在线反思学习框架（REFSEG），以改善细分鲁棒性。基于启用概念的反射概念，我们的refseg首先驱动了深层模型以采取行动以获得语义分割。然后，refseg触发模型以反映自身。因为使深层模型在测试过程中意识到他们的细分失败是具有挑战性的，所以RefSeg合成了从语义面具中综合的逼真的代理图像，以帮助深层模型构建直观有效的反射。该代理翻译并强调了分割缺陷。通过最大程度地提高原始输入和代理之间的结构相似性，可以改善分割鲁棒性的反射循环。 REFSEG在测试阶段运行，并且是分割模型的一般性。通过公共心脏MR数据集和两个内部大型超声数据集对三个医疗图像细分任务进行了广泛的验证，这表明我们的refseg显着提高了模型的鲁棒性，并报告了与强大竞争对手有关的最先进的表现。

超声（US）广泛用于实时成像，无辐射和便携性的优势。在临床实践中，分析和诊断通常依赖于美国序列，而不是单个图像来获得动态的解剖信息。对于新手来说，这是一项挑战，因为使用患者的足够视频进行练习是临床上不可行的。在本文中，我们提出了一个新颖的框架，以综合高保真美国视频。具体而言，合成视频是通过基于给定驾驶视频的动作来动画源内容图像来生成的。我们的亮点是三倍。首先，利用自我监督学习的优势，我们提出的系统以弱监督的方式进行了培训，以进行关键点检测。然后，这些关键点为处理美国视频中的复杂动态动作提供了重要信息。其次，我们使用双重解码器将内容和纹理学习解除，以有效地减少模型学习难度。最后，我们采用了对抗性训练策略，并采用了GAN损失，以进一步改善生成的视频的清晰度，从而缩小了真实和合成视频之间的差距。我们在具有高动态运动的大型内部骨盆数据集上验证我们的方法。广泛的评估指标和用户研究证明了我们提出的方法的有效性。

This paper focuses on designing efficient models with low parameters and FLOPs for dense predictions. Even though CNN-based lightweight methods have achieved stunning results after years of research, trading-off model accuracy and constrained resources still need further improvements. This work rethinks the essential unity of efficient Inverted Residual Block in MobileNetv2 and effective Transformer in ViT, inductively abstracting a general concept of Meta-Mobile Block, and we argue that the specific instantiation is very important to model performance though sharing the same framework. Motivated by this phenomenon, we deduce a simple yet efficient modern \textbf{I}nverted \textbf{R}esidual \textbf{M}obile \textbf{B}lock (iRMB) for mobile applications, which absorbs CNN-like efficiency to model short-distance dependency and Transformer-like dynamic modeling capability to learn long-distance interactions. Furthermore, we design a ResNet-like 4-phase \textbf{E}fficient \textbf{MO}del (EMO) based only on a series of iRMBs for dense applications. Massive experiments on ImageNet-1K, COCO2017, and ADE20K benchmarks demonstrate the superiority of our EMO over state-of-the-art methods, \eg, our EMO-1M/2M/5M achieve 71.5, 75.1, and 78.4 Top-1 that surpass \textbf{SoTA} CNN-/Transformer-based models, while trading-off the model accuracy and efficiency well.

Decompilation aims to transform a low-level program language (LPL) (eg., binary file) into its functionally-equivalent high-level program language (HPL) (e.g., C/C++). It is a core technology in software security, especially in vulnerability discovery and malware analysis. In recent years, with the successful application of neural machine translation (NMT) models in natural language processing (NLP), researchers have tried to build neural decompilers by borrowing the idea of NMT. They formulate the decompilation process as a translation problem between LPL and HPL, aiming to reduce the human cost required to develop decompilation tools and improve their generalizability. However, state-of-the-art learning-based decompilers do not cope well with compiler-optimized binaries. Since real-world binaries are mostly compiler-optimized, decompilers that do not consider optimized binaries have limited practical significance. In this paper, we propose a novel learning-based approach named NeurDP, that targets compiler-optimized binaries. NeurDP uses a graph neural network (GNN) model to convert LPL to an intermediate representation (IR), which bridges the gap between source code and optimized binary. We also design an Optimized Translation Unit (OTU) to split functions into smaller code fragments for better translation performance. Evaluation results on datasets containing various types of statements show that NeurDP can decompile optimized binaries with 45.21% higher accuracy than state-of-the-art neural decompilation frameworks.

Image Virtual try-on aims at replacing the cloth on a personal image with a garment image (in-shop clothes), which has attracted increasing attention from the multimedia and computer vision communities. Prior methods successfully preserve the character of clothing images, however, occlusion remains a pernicious effect for realistic virtual try-on. In this work, we first present a comprehensive analysis of the occlusions and categorize them into two aspects: i) Inherent-Occlusion: the ghost of the former cloth still exists in the try-on image; ii) Acquired-Occlusion: the target cloth warps to the unreasonable body part. Based on the in-depth analysis, we find that the occlusions can be simulated by a novel semantically-guided mixup module, which can generate semantic-specific occluded images that work together with the try-on images to facilitate training a de-occlusion try-on (DOC-VTON) framework. Specifically, DOC-VTON first conducts a sharpened semantic parsing on the try-on person. Aided by semantics guidance and pose prior, various complexities of texture are selectively blending with human parts in a copy-and-paste manner. Then, the Generative Module (GM) is utilized to take charge of synthesizing the final try-on image and learning to de-occlusion jointly. In comparison to the state-of-the-art methods, DOC-VTON achieves better perceptual quality by reducing occlusion effects.

In recent years, the Transformer architecture has shown its superiority in the video-based person re-identification task. Inspired by video representation learning, these methods mainly focus on designing modules to extract informative spatial and temporal features. However, they are still limited in extracting local attributes and global identity information, which are critical for the person re-identification task. In this paper, we propose a novel Multi-Stage Spatial-Temporal Aggregation Transformer (MSTAT) with two novel designed proxy embedding modules to address the above issue. Specifically, MSTAT consists of three stages to encode the attribute-associated, the identity-associated, and the attribute-identity-associated information from the video clips, respectively, achieving the holistic perception of the input person. We combine the outputs of all the stages for the final identification. In practice, to save the computational cost, the Spatial-Temporal Aggregation (STA) modules are first adopted in each stage to conduct the self-attention operations along the spatial and temporal dimensions separately. We further introduce the Attribute-Aware and Identity-Aware Proxy embedding modules (AAP and IAP) to extract the informative and discriminative feature representations at different stages. All of them are realized by employing newly designed self-attention operations with specific meanings. Moreover, temporal patch shuffling is also introduced to further improve the robustness of the model. Extensive experimental results demonstrate the effectiveness of the proposed modules in extracting the informative and discriminative information from the videos, and illustrate the MSTAT can achieve state-of-the-art accuracies on various standard benchmarks.

It has been observed in practice that applying pruning-at-initialization methods to neural networks and training the sparsified networks can not only retain the testing performance of the original dense models, but also sometimes even slightly boost the generalization performance. Theoretical understanding for such experimental observations are yet to be developed. This work makes the first attempt to study how different pruning fractions affect the model's gradient descent dynamics and generalization. Specifically, this work considers a classification task for overparameterized two-layer neural networks, where the network is randomly pruned according to different rates at the initialization. It is shown that as long as the pruning fraction is below a certain threshold, gradient descent can drive the training loss toward zero and the network exhibits good generalization performance. More surprisingly, the generalization bound gets better as the pruning fraction gets larger. To complement this positive result, this work further shows a negative result: there exists a large pruning fraction such that while gradient descent is still able to drive the training loss toward zero (by memorizing noise), the generalization performance is no better than random guessing. This further suggests that pruning can change the feature learning process, which leads to the performance drop of the pruned neural network. Up to our knowledge, this is the \textbf{first} generalization result for pruned neural networks, suggesting that pruning can improve the neural network's generalization.

This work studies training one-hidden-layer overparameterized ReLU networks via gradient descent in the neural tangent kernel (NTK) regime, where, differently from the previous works, the networks' biases are trainable and are initialized to some constant rather than zero. The first set of results of this work characterize the convergence of the network's gradient descent dynamics. Surprisingly, it is shown that the network after sparsification can achieve as fast convergence as the original network. The contribution over previous work is that not only the bias is allowed to be updated by gradient descent under our setting but also a finer analysis is given such that the required width to ensure the network's closeness to its NTK is improved. Secondly, the networks' generalization bound after training is provided. A width-sparsity dependence is presented which yields sparsity-dependent localized Rademacher complexity and a generalization bound matching previous analysis (up to logarithmic factors). As a by-product, if the bias initialization is chosen to be zero, the width requirement improves the previous bound for the shallow networks' generalization. Lastly, since the generalization bound has dependence on the smallest eigenvalue of the limiting NTK and the bounds from previous works yield vacuous generalization, this work further studies the least eigenvalue of the limiting NTK. Surprisingly, while it is not shown that trainable biases are necessary, trainable bias helps to identify a nice data-dependent region where a much finer analysis of the NTK's smallest eigenvalue can be conducted, which leads to a much sharper lower bound than the previously known worst-case bound and, consequently, a non-vacuous generalization bound.

Deep learning has been widely used for protein engineering. However, it is limited by the lack of sufficient experimental data to train an accurate model for predicting the functional fitness of high-order mutants. Here, we develop SESNet, a supervised deep-learning model to predict the fitness for protein mutants by leveraging both sequence and structure information, and exploiting attention mechanism. Our model integrates local evolutionary context from homologous sequences, the global evolutionary context encoding rich semantic from the universal protein sequence space and the structure information accounting for the microenvironment around each residue in a protein. We show that SESNet outperforms state-of-the-art models for predicting the sequence-function relationship on 26 deep mutational scanning datasets. More importantly, we propose a data augmentation strategy by leveraging the data from unsupervised models to pre-train our model. After that, our model can achieve strikingly high accuracy in prediction of the fitness of protein mutants, especially for the higher order variants (> 4 mutation sites), when finetuned by using only a small number of experimental mutation data (<50). The strategy proposed is of great practical value as the required experimental effort, i.e., producing a few tens of experimental mutation data on a given protein, is generally affordable by an ordinary biochemical group and can be applied on almost any protein.

Purpose: Tracking the 3D motion of the surgical tool and the patient anatomy is a fundamental requirement for computer-assisted skull-base surgery. The estimated motion can be used both for intra-operative guidance and for downstream skill analysis. Recovering such motion solely from surgical videos is desirable, as it is compliant with current clinical workflows and instrumentation. Methods: We present Tracker of Anatomy and Tool (TAToo). TAToo jointly tracks the rigid 3D motion of patient skull and surgical drill from stereo microscopic videos. TAToo estimates motion via an iterative optimization process in an end-to-end differentiable form. For robust tracking performance, TAToo adopts a probabilistic formulation and enforces geometric constraints on the object level. Results: We validate TAToo on both simulation data, where ground truth motion is available, as well as on anthropomorphic phantom data, where optical tracking provides a strong baseline. We report sub-millimeter and millimeter inter-frame tracking accuracy for skull and drill, respectively, with rotation errors below 1{\deg}. We further illustrate how TAToo may be used in a surgical navigation setting. Conclusion: We present TAToo, which simultaneously tracks the surgical tool and the patient anatomy in skull-base surgery. TAToo directly predicts the motion from surgical videos, without the need of any markers. Our results show that the performance of TAToo compares favorably to competing approaches. Future work will include fine-tuning of our depth network to reach a 1 mm clinical accuracy goal desired for surgical applications in the skull base.